Free Kappa Light Chains Urine

A free light chains test measures the amount of lambda and kappa free light chains in the blood.

Free kappa light chains urine.

In general the higher the free light chains the more aggressive the disease is. Therefore the serum free light chain test is a better predictor of outcome than the amount of m protein in the blood. The test measures the levels of specific types of free light chains known as kappa and lambda and also the ratio between the two. If a patient has kappa myeloma their doctor will watch for a rise in the kappa numbers.

While the molecular weight of both light chains is approximately 22 5 kilodaltons in serum κ free light chain κ flc exists primarily as a monomer and λ free light chain λ flc as a covalently linked dimer with a molecular weight of approximately 45 kilodaltons. The results of urine kappa and lambda free light chains must be interpreted in conjunction with urine immunofixation. What are light chains. Lambda and kappa light chains.

5 71 to 26 3 mg l lambda free light chains. A greater than 90 decrease suggests treatment response. A k l ratio less than 0 7 suggests the presence of monoclonal lambda light chains. 0 26 to 1 65 ratio of kappa lambda.

Please provide service area information to confirm test code for the lab that services your account or to find available tests you can order. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. Results of urine free light chain testing can be used to monitor disease progression or response to therapy in patients for whom urine electrophoresis is unable to provide reliable bence jones protein quantification. Normal test results for free light chains are.

San juan capistrano ca. In 24 hour specimens a greater than 90 increase in concentration suggests progression or relapse. There are two types of light chains. There are two types of light chains.

3 3 to 19 4 mg l kappa free light chains. These unlinked chains are known as free light chains.